Isabella of Castille Small 281×320 Medium 563×640 Large 900×1024 Download Tiff Original 2110×2400 | (5.0 MB) Description Isabella I (April 22, 1451 – November 26, 1504) was Queen of Castile and León. She and her husband, Ferdinand II of Aragon, laid the foundation for the political unification of Spain under their grandson, Charles V, Holy Roman Emperor. Keywords Catholic Monarchs, Ferdinand II, Holy Roman Empire, kqueen, portrait, Queen of Castile, unification of Spain Galleries Famous People: I-J, Queens Source: Benson John Lossing, ed. Harper's Encyclopedia of United States History (vol. 5) (New York, NY: Harper and Brothers, 1912)