Isabella of Castille
Isabella I (April 22, 1451 – November 26, 1504) was Queen of Castile and León. She and her husband, Ferdinand II of Aragon, laid the foundation for the political unification of Spain under their grandson, Charles V, Holy Roman Emperor.
Benson John Lossing, ed. Harper's Encyclopedia of United States History (vol. 5) (New York, NY: Harper and Brothers, 1912)