Effect of Tannin on Red Blood Cells
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When a 2 percent fresh solution of tannic acid is applied to frog’s blood it causes the appearance of a sharply defined little knob, projecting from the free surface (Robert’s macula): the coloring matter becomes at the same concentrated in the nucleus, which grows more distinct. A somewhat similar effect is produced on the human blood corpuscle.
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Cellular BiologySource
Baker, W. Morrant & Harris, Vincent Dormer Kirkes' Hand-book of Physiology, 13th ed. (Philadelphia: P. Blakiston's Son & Co., 1892) 142
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